Analytical chemistry

Combining strong scientific and regulatory knowledge with state-of-the art technologies, the ERBC’s analytical chemistry team conducts feasibility studies and set-up and validates new testing methods. All studies are performed in a GLP facility and clinical study samples are managed in agreement with GCP requirements (FDA and EMA guidelines).

Preclinical and clinical samples analysis

Including logistical services

Method development/transfer and validation

Solid phase extraction, liquid/liquid extraction, protein precipitation plate, ultra-centrifugation and micro dialysis

Microsampling plasma/blood

Dried blood spot, volumetric blood micro extraction (VAMS), capillary micro sampling

Formulation and stability analysis

Solutions, suspensions, diet

PK/TK samples analysis

All biological fluids and tissues

Metabolite stability assays and identification

High Resolution Mass Spectrometry

Oxidative metabolism

Drug- Drug Interaction studies

Cytochrome P450 direct inhibition
Cytochrome P450 time dependent inhibition
Cytochrome P450 induction

Protein binding studies

Antibody studies

PK/TK studies
DAR characterization of ADC

Skin absorption studies (OECD 428)

Analysis of Veterinary Residues in Animal Tissues

Solid phase and liquid-liquid extraction, protein precipitation plate