Discovery

ERBC leverages innovative CellDX (cancer cell line derived Xenograft) and PDX (Patient-Derived Xenograft) models to accelerate cancer research and therapy development. Our AVI-cellDXTM AVI-PDX™ model, developed using avian embryos, enables rapid tumor formation and therapeutic evaluation, within a week. The model creates miniature, patient-specific tumors within the embryo, providing a powerful tool for drug testing and comparison with SOC. Tumorigenesis is targeted through orthotopic implantation in tissues homologous to those in which primary tumors develop or where metastasis is known to occur, ensuring high relevance and accuracy. Utilizing state-of-the- art 3D lightsheet imaging and molecular analysis capabilities, we are able to track tumor progression, monitor treatment efficacy, and explore molecular profiles that inform therapeutic decisions.

To detect potential safety risks at an early stage, ERBC conducts Early Safety evaluations, which combine in vitro and in vivo toxicity assays across rodent and non-rodent species. These studies, including exploratory safety programs and predictive biomarkers, help identify adverse effects such as mutagenicity, cardiovascular toxicity, or neurological impacts. Through optimized study designs and reduced animal numbers, we achieve low-cost, high-quality results. Reports are delivered within two weeks of the final experimental phase, ensuring quick decision-making.

At ERBC, we perform comprehensive tolerability studies to evaluate the safety profile of your compounds in early drug development. Our studies help identify the tolerated dose of a compound, ensuring that it is safe for progression to clinical trials. We conduct these studies across a range of species, including rodents and non-rodents, to assess both single and repeated administrations of the compound.

ERBC maintains accredited BSL-2 and BSL-3 animal facilities, totaling 400 m², to safely conduct research involving infectious agents requiring moderate to high containment. These facilities are equipped to house a diverse range of small animal species.