CellDX and PDX Models

CellDX and PDX Models

Our AVI-PDX™ and AVI-cellDX™ models

Oncofactory operates a unique technological platform exploiting an innovative patient-derived xenograft (PDX) animal model, the avian embryo. Miniature replicas of tumors from patient samples (AVI-PDX™) or from cell lines (AVI-cellDX™) are created in a series of embryos, which can receive therapeutic treatments.

Our technology allows modeling the heterogeneity of patient tumors, statistical analysis of treatment efficacies, and a range of molecular analyses for biomarker and therapeutic target discovery.

The AVI-PDX™ model of Oncofactory holds the unique advantage of allowing the creation of tumors and the delivery of therapeutic compounds (small molecule, targeted therapy, immunotherapy) in only a few days. Moreover, the tumorigenesis is targeted onto tissues which are homologous to those in which primary tumors emerge in the patient or in known sites of metastasis. Tumor replicas are imaged in 3D in the entire organism by using high resolution confocal microscopy. A range of molecular analyses can also be conducted on tumor replicas, host tissues and fluids, to achieve a molecular profiling characterizing the sensitivity and resistance to treatments.

Our AVI-Tumoral models

Our most recent R&D achievement: iAVI-models to evaluate immunotherapy in mono and combi-therapies

AVI-cellDX™

CELL LINES

AVI-PDX™

PATIENT BIOPSIES

iAVI-cellDX™

CELL LINES
Humanized with immune cells

iAVI-cellDX™

PATIENT BIOPSIES
Humanized with immune cells

This technology is protected by 2 patents :
1.EP 3 167 048 B1 • 2.WO 2017/103025

Graft of patient sample into the embryo

  • Tissues and organs are already prefigured in the embryo
  • Due to high degree of inter-specie conservation, human cells can read the signals from the avian microenvironment

KEY ADVANTAGES

  • Tumorigenesis is targeted into selected territories corresponding to patient primary tumor sites or to known metastatic sites.
  • Cancer cells exploit tissue specific signals to proliferate and to establish metastases.