Regulatory toxicology

To establish the toxicological profile of new compounds or to extend the known profiles of existing one (new indications, new formulations, new routes of administration…), ERBC offers a full range of services covering from exploratory programs to fully GLP-compliant toxicology studies. The latter range from acute to chronic toxicity, with different species and multiple routes of administration, to specialty toxicology. These data support human clinical trials and marketing authorization approval around the world.

Today, the company is a leading innovator in the discipline. ERBC scientists develop advanced tools, assays and models that contribute to reduce the use of animals and improve data predictivity and participate in interdisciplinary working groups that shape the future of toxicology.

Equipment and infrastructure

Toxicology suite

Surgical rooms

Data center

Analytics lab

Animal facilities (dedicated facilities for each specie)

Models

Our validated and ethical animal models provide predictive insights, bridging preclinical research with human relevance. By integrating 3Rs principles and NAMs, we ensure refined, reliable, and tailored study designs for diverse industry needs.

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Routes of administration

To comply with the guidelines on the design of toxicity studies, “the choice of the route of administration of a given compound should depend on the physical and chemical characteristics of the test substance, its intended field of application, the availability of information on shorter-term repeat dose studies and the predominant route of anticipated human exposure”. For example, while an oral administration will be favored if human exposure to the test substance is most likely to be through food, other administration routes might be more appropriate to test other substances such as pharmaceuticals (intravenous or subcutaneous routes).

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Toxicology

At ERBC, we provide a full range of regulatory and investigative toxicology services to assess the safety of pharmaceuticals, chemicals, agrochemicals, cosmetics, and medical devices, ensuring compliance with international standards.

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